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It produces high-quality alignments of protein sequences from a database or a protein query and compares them to a protein sequence database. The sequence-to-sequence alignment algorithm uses the probabilistic HMM models to align sequences. It has a large speed and memory footprint advantage over other existing alignment programs such as BLAST or BLASTP. Version : 3.0 Date : 2008-06-21 Author : Andre Le Dantec Licence : GNU General Public License version 3 Website : [Regulation of biological processes by cyclic AMP--from molecules to cells and tissues]. Cyclic AMP (cAMP) is one of the most important second messengers in the mammalian organism. Its presence in the cytoplasm is generated by the activity of the enzyme adenylate cyclase, which converts ATP into cAMP. The latter is a powerful activator of protein kinase A (PKA), which in turn phosphorylates a series of proteins involved in diverse signal transduction cascades. In fact, in most eukaryotic organisms cAMP is involved in regulating a variety of cellular processes including proliferation, differentiation, metabolism, etc. Many of these processes are mediated by cAMP-dependent protein kinase effectors, and it is likely that cAMP may be one of the key regulators of many, if not all, such processes. On the other hand, there is growing evidence that cAMP is a key mediator of cellular functions in a number of processes, including immune system activation and the response to viral infection, in a variety of tissues, including neuronal and vascular smooth muscle, and in the secretion of hormones and neurotransmitters. As such, cAMP could be responsible for some aspects of the cellular and physiological responses elicited in the organism by external signals and by drugs. 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